[Blood lactate and biguanide therapy: comparison between phenformin, metformin and buformin in 408 senile diabetics]

In our series of patients, blood lactate is investigated in type II-diabetics under sulfonylurea or sulfonylureabiguanid treatment. Under biguanides a statistically significant increase of blood lactate is found dose-dependent, but independent of the type of biguanides used.