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Effects of B subunit of cholera toxin on histamine release from rat peritoneal mast cells
K Sugimoto1, F Kasuga, S Kumagai
1Department of Biomedical Food Research, National Institute of Health, Tokyo, Japan.
International Archives of Allergy and Immunology
|October 1, 1994
Abstract:
We studied the effects of B subunit of cholera toxin (CTB) on secretagogue-induced histamine release from rat peritoneal mast cells. CTB inhibited the release of histamine in response to compound 48/80, but not in response to mastoparan, substance P, concanavalin A or ionophore A23187. The results suggest that CTB can be used as a tool for studying the cellular events involved in histamine release from mast cells.