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Leukotrienes C4 and D4 promote angiogenesis via a receptor-mediated interaction
N E Tsopanoglou1, E Pipili-Synetos, M E Maragoudakis
1Department of Pharmacology, Medical School, University of Patras, Greece.
European Journal of Pharmacology
|June 2, 1994
Abstract:
The involvement of leukotrienes in angiogenesis was investigated in the in vivo chick chorioallantoic membrane system. In this system leukotrienes C4 and D4 promoted angiogenesis in a dose-dependent manner. Leukotriene B4 was ineffective. The potent and selective peptidyl leukotriene receptor antagonist, SK&F 104353-Z2, abolished the angiogenic effects of leukotrienes C4 and D4 and reduced unstimulated angiogenesis. These results indicate that leukotrienes C4 and D4 promote angiogenesis in the chick chorioallantoic membrane via a receptor-mediated interaction.