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Involvement of the brain type of ryanodine receptor in T-cell proliferation
Y Hakamata1, S Nishimura, J Nakai
1Department of Geriatric Medicine, Kyoto University Faculty of Medicine, Japan.
FEBS Letters
|September 26, 1994
Abstract:
Cloning and sequence analysis of cDNA showed that the brain type of ryanodine receptor (RYR) is expressed in human Jurkat T-lymphocyte cells. Fura-2 measurements revealed that the RYR in T-cells functions as a ryanodine-sensitive, caffeine-insensitive Ca2+ release channel. Furthermore, ryanodine stimulated proliferation and altered the growth pattern of cultured human T-cells when added together with FK506.