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pH and temperature modulate norepinephrine-dependent changes in endothelial permeability

M P Griffin1, J R Moorman

  • 1Department of Pediatrics, University of Virginia, Charlottesville 22901.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|June 1, 1994
PubMed
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Norepinephrine (NE) reduces endothelial permeability, but this effect is weakened by low pH and high temperatures. Fever and acidosis may worsen edema in septic shock by impairing NE's barrier function.

Area of Science:

  • Physiology
  • Biochemistry
  • Pathology

Background:

  • Endothelial permeability is crucial for vascular function.
  • Norepinephrine (NE) is known to decrease endothelial permeability.
  • Septic shock can lead to edema, but the underlying mechanisms are not fully understood.

Purpose of the Study:

  • To investigate the influence of pH and temperature on NE-mediated endothelial permeability.
  • To explore potential mechanisms contributing to edema in septic shock.

Main Methods:

  • Studied bovine pulmonary arterial endothelial monolayers.
  • Exposed cells to a range of pH values (4-9) and temperatures (35-39°C).
  • Assessed the effects of NE and 3-isobutyl-1-methylxanthine on endothelial permeability.

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Main Results:

  • Extreme pH values modulated endothelial permeability.
  • Temperature variations (35-39°C) did not significantly affect permeability.
  • Both NE and 3-isobutyl-1-methylxanthine decreased permeability, but this effect was reduced at low pH and high temperatures.

Conclusions:

  • Low pH and high temperatures can attenuate the barrier-enhancing effects of NE.
  • Fever and acidosis associated with septic shock may exacerbate edema by inhibiting NE's protective function.
  • This highlights a novel mechanism contributing to edema in septic shock.