Cardiac response to autonomic drugs in atria of diabetic mouse

Comparisons of chronotropic effects of sympathomimetic and parasympathomimetic agents were made in isolated atria from alloxan-induced diabetic and age-matched control mice. In atria from mice rendered diabetic for three months, the cardiac response to bethanechol was potentiated compared with that of the age-matched control atria. However, the cardiac responses of atria from alloxan-treated mice to noradrenaline, 3-isobutyl-1-methyl-xanthine and 1,1-dimethyl-4-phenyl piperazinium iodide were similar to those of the controls.