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Perindopril and physiologic responses to exercise

E Q Klug1, B I Joffe, V R Panz

  • 1Division of Cardiology, University of Witwatersrand, Johannesburg Hospital, South Africa.

Journal of Cardiovascular Pharmacology
|June 1, 1994
PubMed
Summary
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Perindopril, an ACE inhibitor, effectively lowers blood pressure during rest and exercise in healthy individuals. It also increases blood potassium and glucose levels without altering hormonal responses to physical activity.

Area of Science:

  • Cardiology
  • Exercise Physiology
  • Pharmacology

Background:

  • Cardiovascular drugs impact exercise responses.
  • Angiotensin-converting enzyme (ACE) inhibitors are commonly prescribed.
  • Understanding perindopril's exercise effects is crucial.

Purpose of the Study:

  • To evaluate perindopril's effects on hemodynamic, metabolic, and hormonal responses during exercise.
  • To assess changes in blood pressure, heart rate, and key metabolic markers.
  • To investigate hormonal alterations during physical exertion under perindopril therapy.

Main Methods:

  • Double-blind, randomized, placebo-controlled trial.
  • 9 healthy volunteers participated.
  • Treadmill effort tests were conducted after perindopril or placebo administration.

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Main Results:

  • Perindopril significantly reduced resting and post-exercise systolic and diastolic blood pressure.
  • No significant differences in metabolic or hormonal profiles were observed between perindopril and placebo groups.
  • Perindopril induced modest increases in serum potassium and plasma glucose concentrations post-exercise.

Conclusions:

  • Perindopril does not impair exercise-induced hormonal changes in healthy subjects.
  • Perindopril therapy leads to consistent increases in blood potassium and glucose during exercise.
  • Perindopril demonstrates favorable hemodynamic effects during exercise without adverse metabolic or hormonal disruptions.