Resistance to atracurium: Wegener's granulomatosis--a case report

Few previous reports clarified that patients with an increased alpha 1 globulin fraction in their serum protein electrophoresis, will have resistance to the neuromuscular block of atracurium. Having a patient with diagnosis of Wegener's granulomatosis and a marked elevation of alpha 1 globulin fraction in her electrophoresis, we took this opportunity to monitor the neuromuscular block of atracurium. The data obtained, confirm previous studies showing that patients with a marked increase in alpha 1 globulin fraction may have a resistance to the action of atracurium.