Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tradescantia micronucleus bioassay

T H Ma1, G L Cabrera, R Chen

  • 1Department of Biological Sciences, Western Illinois University, Macomb 61455.

Mutation Research
|October 16, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exploring and comparing bracing protocols for acute isolated posterior cruciate ligament injuries: A scoping review of rationales and approaches.

Musculoskeletal science & practice·2025
Same author

Identification of stable heat tolerance QTLs using inter-specific recombinant inbred line population derived from GPF 2 and ILWC 292.

PloS one·2021
Same author

Inheritance and biochemical basis of yellowing of apical leaves: a unique trait in chickpea (<i>Cicer arietinum</i> L.).

Journal of genetics·2021
Same author

A population-based cross-sectional study to determine the practices of breastfeeding among the lactating mothers of Patiala city.

Journal of family medicine and primary care·2019
Same author

Co-existence of Leclercia adecarboxylata (LSE-1) and Bradyrhizobium sp. (LSBR-3) in nodule niche for multifaceted effects and profitability in soybean production.

World journal of microbiology & biotechnology·2019
Same author

Alien chromosome segment from Aegilops speltoides and Dasypyrum villosum increases drought tolerance in wheat via profuse and deep root system.

BMC plant biology·2019
Same journal

Monoallelic germline RAD51C, RAD51D, and BRIP1 variants in hereditary cancer testing: Variant spectrum and clinical counselling implications.

Mutation research·2026
Same journal

Prediction of hepatocellular carcinoma associated biomarkers in TP53 gene; A comprehensive in silico analysis.

Mutation research·2026
Same journal

IDH1 mutation promotes angiogenesis via upregulation of hypoxia inducible factor 1 alpha in glial tumors.

Mutation research·2026
Same journal

Targeting overexpressed oncogenes in esophageal cancer through miRNA-mediated gene silencing: Insights from binding affinity and thermodynamic profiling.

Mutation research·2026
Same journal

The active compound quercetin from Polygonum cuspidatum targets COL3A1 to enhance CD8⁺ T cell cytotoxicity in gastric cancer.

Mutation research·2026
Same journal

E2F1 promotes LIHC malignant phenotype via NEK2-mediated Wnt/β-catenin and Notch activation and EMT.

Mutation research·2026
See all related articles

The Tradescantia micronucleus (Trad-MCN) bioassay reliably detects clastogens. This international study confirmed its efficiency for screening chemicals and monitoring environmental pollutants.

Area of Science:

  • Environmental Science
  • Toxicology
  • Genetics

Background:

  • The International Programme on Chemical Safety coordinated a study to assess plant bioassays.
  • The Tradescantia micronucleus (Trad-MCN) assay is a plant-based bioassay used for genotoxicity testing.

Purpose of the Study:

  • To evaluate the sensitivity, efficiency, and reliability of the Trad-MCN bioassay.
  • To assess the Trad-MCN assay's performance in an international collaborative study.

Main Methods:

  • Four coded chemicals (azidoglycerol, N-methyl-N-nitrosourea, sodium azide, maleic hydrazide) were tested.
  • Five independent laboratories followed a standard Trad-MCN protocol with three replicate tests per chemical.

Main Results:

Related Experiment Videos

  • All laboratories reported positive results for maleic hydrazide and N-methyl-N-nitrosourea.
  • Four of five laboratories found sodium azide to be positive.
  • Azidoglycerol yielded mixed results, with one lab reporting positive results only at a high dose.

    • Conclusions:

    • The Trad-MCN bioassay is an efficient and reliable short-term assay for clastogens under normal conditions.
    • The assay is suitable for rapid chemical screening and in situ monitoring of ambient pollutants.