Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nitric oxide in the rat vestibular system

A Harper1, W R Blythe, C J Zdanski

  • 1Division of Otolaryngology/Head and Neck Surgery, University of North Carolina School of Medicine, Chapel Hill 27599-7070.

Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
|October 1, 1994
PubMed
Summary

Nitric oxide (NO), a neurotransmitter in the brain, was found to be active in the rat vestibular system. This suggests NO may modulate balance and hearing neurotransmission.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fetal Alcohol Spectrum Disorder in Ireland.

Irish medical journal·2026
Same author

Atrial fibrillation and non-ischaemic cardiomyopathy in the peripartum period.

Anaesthesia reports·2020
Same author

Toxicity of cytarabine constant rate infusion in dogs with high-grade non-Hodgkin lymphoma with bone marrow or central nervous system involvement.

Australian veterinary journal·2019
Same author

MSTO1 mutations cause mtDNA depletion, manifesting as muscular dystrophy with cerebellar involvement.

Acta neuropathologica·2019
Same author

Biogenic Amine Production by and Phylogenetic Analysis of 23 Photobacterium Species.

Journal of food protection·2018
Same author

Outpatient management and surgeon specialty for thyroglossal duct cyst excision: A retrospective analysis of 377 patients and 30-day outcomes in the American College of Surgeons NSQIP-P Database.

Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·2018

Area of Science:

  • Neuroscience
  • Vestibular System Research
  • Biochemistry

Background:

  • Nitric oxide (NO) acts as a neurotransmitter in the central nervous system.
  • Excitatory amino acids, like glutamate and aspartate, are present in the vestibular system and may function as neurotransmitters.
  • NO's role in the vestibular system has not been previously studied.

Purpose of the Study:

  • To investigate the presence and activity of nitric oxide synthase (NOS) in the rat vestibular system.
  • To determine if NO plays a role in vestibular neurotransmission.

Main Methods:

  • Used a histochemical stain specific for neuronal NOS to localize the enzyme in rat vestibular tissue.
  • Employed immunocytochemical staining to detect L-citrulline, an end product of NOS, indicating NOS activity.

Related Experiment Videos

  • Examined vestibular ganglion sections for NOS presence and activity.

    • Main Results:

    • Nitric oxide synthase was localized in vestibular ganglion cells and nerve fibers.
    • Evidence of active nitric oxide synthase was found in the rat vestibular system.
    • The enzyme's end product, L-citrulline, was detected, confirming NOS activity.

    Conclusions:

    • The study demonstrates the presence and activity of nitric oxide synthase in the rat vestibular system.
    • These findings suggest that nitric oxide may modulate neurotransmission within the vestibular system.
    • This research opens new avenues for understanding the neurochemistry of balance and spatial orientation.