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The signal recognition particle database (SRPDB)

C Zwieb1, N Larsen

  • 1Department of Molecular Biology, University of Texas Health Science Center, Tyler 75710.

Nucleic Acids Research
|September 1, 1994
PubMed
Summary
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The Signal Recognition Particle Database (SRPDB) offers aligned SRP RNA and protein sequences, aiding research in molecular biology. This release includes updated sequence data and RNA structures for signal recognition particle components.

Area of Science:

  • Molecular Biology
  • Genomics
  • Bioinformatics

Background:

  • The Signal Recognition Particle (SRP) pathway is crucial for targeting proteins to cellular membranes.
  • Comprehensive sequence and structural data are essential for understanding SRP function and evolution.

Purpose of the Study:

  • To update and expand the Signal Recognition Particle Database (SRPDB) with new sequence and structural information.
  • To provide researchers with a curated resource for studying signal recognition particle components.

Main Methods:

  • Curated collection and alignment of SRP RNA and protein sequences.
  • Phylogenetic ordering of collected sequences.
  • Generation of representative RNA secondary structure diagrams.

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Main Results:

  • The database now contains 82 SRP RNAs, including bacterial and archaeal homologs.
  • A total of 20 protein sequences (SRP9, SRP14, SRP19, SRP54, SRP68, SRP72) are included.
  • Annotated sequence data and RNA secondary structure diagrams are available.

Conclusions:

  • The updated SRPDB serves as a valuable, comprehensive resource for the scientific community.
  • Facilitates further research into the structure, function, and evolution of the signal recognition particle system.