[Correlation between bone gammagraphy and biochemical parameters in bone turnover in patients with prostate cancer]

Evaluation of osteocalcin (BGP), hydroxyproline/creatinine (HxP/Cr) and PSA values in 43 patients with prostate cancer, 25 with spread disease (bone metastasis) and 18 with no bone dissemination. Correlation of values obtained with the patient's clinical status: complete response, partial response, steady state and progression. Mann-Whitney's U test shows statistical significance (P < 0.001) when patient's PSA values are compared to non-disseminated disease with regard to those with bone metastasis, the same result being obtained with the HxP/Cr ratio. Comparison of BGP figures within the same groups did not reach statistical significance, although the number of patients with abnormally high BGP values was considered to be much higher in patients with disseminated (52%) versus non-disseminated (11%) condition. We conclude that both a deeper knowledge of bone dynamics in these patients and, therefore, evolutive follow-up of bone turnout and resorption is required in order to establish clinically useful criteria.