Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intestinal anaphylaxis: radiation-induced suppression

Y Harari1, D Kester, E Travis

  • 1Department of Physiology, University of Texas Medical School at Houston.

The American Journal of Physiology
|October 1, 1994
PubMed
Summary

Ionizing radiation significantly suppresses gastrointestinal mucosal immune responses, particularly mast cell and epithelial involvement. The duration and severity of this suppression are directly related to the radiation dose received.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Rockefeller Foundation support for the development of penicillin.

Irish medical journal·2026
Same author

Analytical challenges and occurrence of antibiotics in biosolids from municipal sewage treatment plants in North Spain.

Journal of chromatography. A·2026
Same author

The Rockefeller Foundation and its attempts to develop medical education in 1922.

Irish medical journal·2025
Same author

Assessment of LC-QTOF-MS data independent acquisition for quantification and suspect screening of pesticides in agriculture impacted water samples.

Journal of chromatography. A·2025
Same author

Rockefeller Foundation Fellowships and Medical Education,1925-1936.

Irish medical journal·2024
Same author

Versatile multi-energy hard x-ray camera to study confined and unconfined fast electron dynamics and anisotropies (Invited).

The Review of scientific instruments·2024

Area of Science:

  • Immunology
  • Gastroenterology
  • Radiation Biology

Background:

  • The gastrointestinal tract contains radiosensitive mast cells and epithelial cells crucial for mucosal immunity.
  • Ionizing radiation exposure can impair immune responses within the gut.

Purpose of the Study:

  • To test the hypothesis that irradiation suppresses mast cell and epithelium-dependent mucosal immune responses.
  • To investigate the impact of ionizing radiation on antigen-induced chloride secretion in rat jejunum.

Main Methods:

  • Rats infected with Trichinella spiralis were irradiated with 5, 7, or 9 Gy of gamma radiation.
  • Antigen-induced chloride secretion was measured electrophysiologically in jejunal segments at various time points postirradiation.
  • Responsiveness to exogenous secretagogues was assessed to differentiate radiation effects from epithelial dysfunction.

Related Experiment Videos

Main Results:

  • Radiation dose-dependently suppressed jejunal immune responsiveness to antigenic challenge.
  • Recovery of immune function varied with radiation dose, with complete recovery by 5 days postirradiation at 5 Gy.
  • Higher doses (7 and 9 Gy) resulted in prolonged or complete suppression of immune responses throughout the 21-day observation period.

Conclusions:

  • Ionizing radiation significantly suppresses gastrointestinal mucosal immune responses.
  • The immunosuppressive effects are mediated by mechanisms beyond simple epithelial secretory dysfunction.
  • Radiation dose is a critical determinant of the duration and extent of gut immune suppression.