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Hydration and percutaneous absorption

B Idson

    Current Problems in Dermatology
    |January 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Skin hydration significantly impacts percutaneous absorption. Even when highly hydrated, the stratum corneum (SC) maintains its barrier function due to its unique ultrastructure and keratin composition.

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    Area of Science:

    • Dermatology
    • Biophysics
    • Materials Science

    Background:

    • The stratum corneum (SC) is the primary barrier of the skin, regulating water transport.
    • Skin hydration is a critical factor influencing the percutaneous passage of substances.
    • Disruptions in keratinization, as seen in diseased skin, compromise the SC's barrier function.

    Purpose of the Study:

    • To investigate the role of stratum corneum hydration in the diffusion of substances.
    • To understand how SC hydration affects transepidermal water loss (TEWL).
    • To elucidate the biophysical mechanisms underlying SC permeability and water impermeability.

    Main Methods:

    • The study likely involved biophysical measurements of water content and diffusion rates through SC.
    • Analysis of SC swelling and water absorption upon immersion.

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  • Examination of the relationship between hydration levels and permeability coefficients.

    • Main Results:

    • SC hydration is a key determinant of percutaneous absorption rates.
    • Extensive hydration does not significantly impair the SC's barrier function.
    • The SC swells considerably in water, binding water within intracellular keratin.
    • Despite increased permeability with hydration, the SC remains highly water impermeable.

    Conclusions:

    • The intrinsic low diffusivity and ultrastructure of intracellular keratin are primary factors in SC barrier function.
    • The SC's barrier integrity is maintained even under conditions of high hydration.
    • Understanding SC hydration is crucial for drug delivery and managing skin conditions.