Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

B-cell prolymphocytic leukemia expressing CD13 antigen

A Matsushita1, K Nagai, T Ishikawa

  • 1Department of Immuno-Hematology, Kobe City General Hospital, Japan.

International Journal of Hematology
|August 1, 1994
PubMed
Summary

This study reports a rare case of B-cell prolymphocytic leukemia (B-PLL) in a 74-year-old female. The leukemia cells uniquely expressed the myeloid-associated antigen CD13, alongside typical B-cell markers.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Formation and evolution of carbonaceous asteroid Ryugu: Direct evidence from returned samples.

Science (New York, N.Y.)·2022
Same author

Pebbles and sand on asteroid (162173) Ryugu: In situ observation and particles returned to Earth.

Science (New York, N.Y.)·2022
Same author

Variations in color and reflectance on the surface of asteroid (101955) Bennu.

Science (New York, N.Y.)·2020
Same author

Sample collection from asteroid (162173) Ryugu by Hayabusa2: Implications for surface evolution.

Science (New York, N.Y.)·2020
Same author

An artificial impact on the asteroid (162173) Ryugu formed a crater in the gravity-dominated regime.

Science (New York, N.Y.)·2020
Same author

Journal of Artificial Organs 2019: the year in review : Journal of Artificial Organs Editorial Committee.

Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs·2020

Area of Science:

  • Hematology
  • Immunology
  • Oncology

Background:

  • Myeloid-associated antigen CD13 expression is typically observed in aggressive B-cell chronic lymphocytic leukemia.
  • Its presence in other mature B-cell neoplasms is considered rare.

Observation:

  • A 74-year-old female presented with splenomegaly and hematological findings consistent with B-cell prolymphocytic leukemia (B-PLL).
  • Flow cytometry analysis revealed that the B-PLL cells expressed CD13 antigen simultaneously with B-cell markers CD19 and CD20.
  • Immunoglobulin gene rearrangement was detected, but not TCR-beta gene rearrangement.

Findings:

  • The B-PLL cells expressed a unique immunophenotype including CD11b, CD13, CD19, CD20, CD24, HLA-DR, FMC7, mu, and lambda.
  • Dual-color flow cytometry confirmed the co-expression of CD13 and CD19 on the malignant cells.

Related Experiment Videos

  • Cytogenetic analysis identified an abnormal karyotype involving chromosomes 1, 7, 10, 12, 14, and 15.

    • Implications:

    • This case expands the known immunophenotypic spectrum of B-cell prolymphocytic leukemia.
    • The co-expression of CD13 in B-PLL may warrant further investigation into its diagnostic and prognostic significance.
    • Understanding aberrant antigen expression aids in refining B-cell neoplasm classification and targeted therapy development.