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Treatment of linear localized scleroderma with the anti-allergic drug, tranilast
S Taniguchi1, T Yorifuji, T Hamada
1Department of Dermatology, Osaka City University Medical School, Japan.
Clinical and Experimental Dermatology
|September 1, 1994
Abstract:
A 14-year-old boy with linear localized scleroderma had a dramatic improvement in contractures after treatment with N-(3',4'-dimethoxycinnamoyl) anthranilic acid (tranilast, Rizaben). The observation that this anti-allergic drug was effective in localized scleroderma lends further support to the concept that mast cells play a role in increased collagen synthesis in this disease.