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Tissue repair: a critical determinant in CCl4 hepatotoxicity
E J Calabrese1, D A Leonard, L A Baldwin
1School of Public Health, University of Massachusetts, Amherst 01003.
Ecotoxicology and Environmental Safety
|February 1, 1994
Abstract:
A single antimitotic dose of colchicine administered 24 hr after a single ip dose of CCl4 profoundly enhanced lethality in the adult Sprague-Dawley male rat from < 10% to over > or = 70% within the next 24 hr. These findings suggest that disruption of normal hepatic cellular repair processes is a critical factor affecting the outcome of CCl4 intoxication.