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Updated: Aug 13, 2026
Peptide Scanning-assisted Identification of a Monoclonal Antibody-recognized Linear B-cell Epitope
Published on: March 24, 2017
Antibody response to a Babesia bigemina rhoptry-associated protein 1 surface-exposed and neutralization-sensitive
T C Ushe1, G H Palmer, L Sotomayor
1Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164-7040.
Abstract:
Protective immunity against Babesia bigemina is hypothesized to involve antibodies directed against merozoite surface-exposed epitopes. Levels of antibody against a rhoptry-associated protein 1 (RAP-1) B-lymphocyte epitope, defined by surface-reactive and inhibitory monoclonal antibodies, in immune cattle sera were determined. All cattle produced antibodies to the epitope; however, there was limited correlation between immune protection induced by infection or RAP-1 immunization and the level of antibody to the neutralization-sensitive B-lymphocyte epitope examined.
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