Related Experiment Videos
The effects of clozapine on neurocognition: an overview
1Clinical Brain Disorders Branch, National Institute of Mental Health Neurosciences Center, St. Elizabeths, Washington, D.C. 20032.
The Journal of Clinical Psychiatry
|September 1, 1994
Abstract:
Clozapine has proved effective in alleviating a wide range of psychiatric symptoms in schizophrenia. Its effects on cognitive function in schizophrenia are more variable. Clozapine appears to have a salutary effect on some aspects of attention, response speed, and fluency, whereas it appears to have a mild but adverse effect on visual memory and some executive functions. This profile may be related to the affinity of clozapine for dopaminergic type I and muscarinic receptors and relative lack of affinity for dopaminergic type II receptors.