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Updated: Aug 2, 2026

Live-cell Measurement of Odorant Receptor Activation Using a Real-time cAMP Assay
Published on: October 2, 2017
Transduction diversity in olfaction
1Boston University Marine Program, Marine Biological Laboratory, Woods Hole, MA 02543.
Abstract:
Odors are powerful stimuli that can focus the attention, elicit behaviors (or misbehaviors) and even resurrect forgotten memories. These actions are directed by the central nervous system, but they depend upon the initial transduction of chemical signals by olfactory receptor neurons. Electrophysiological recordings suggest that the responses of olfactory receptor neurons to odors are more diverse than was initially believed, being mediated by effects on several different conductances. Both excitatory and inhibitory responses are produced by these effects and some, if not all, odors can affect more than one component of the membrane conductance. The extent of this diversity is reviewed here, and its impact on our understanding of odor discrimination is discussed.
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