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Dermal vascularity in lentigo maligna

M J Trotter1, V A Tron

  • 1Department of Pathology, Vancouver General Hospital, B.C., Canada.

The Journal of Pathology
|August 1, 1994
PubMed
Summary
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Increased dermal vascularity is linked to invasive lentigo maligna melanoma (LMM). While in situ lentigo maligna (LM) shows some vascular changes, significant increases in dermal vascular density are associated with the presence of invasive LMM.

Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Lentigo maligna (LM) is a melanoma in situ, potentially lacking invasive capacity.
  • The transition from LM to invasive lentigo maligna melanoma (LMM) may involve angiogenic changes.

Purpose of the Study:

  • To investigate the role of dermal vascularity in the progression of LM to LMM.
  • To determine if increased dermal vascularization is associated with invasive LMM development.

Main Methods:

  • Analysis of formalin-fixed, paraffin-embedded tissue from 15 LMM and 11 LM excision specimens.
  • Immunohistochemical staining using Ulex europaeus agglutinin I to identify vascular endothelial cells.
  • Quantitative assessment of dermal vessel count and morphometry.

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Main Results:

  • Dermal vascularity was significantly increased in LM specimens with co-existing LMM compared to normal skin.
  • Dermal vascular density increased by 39% (P=0.008) and total vessel surface area by 62% (P=0.005) in the presence of LMM.
  • LM specimens without invasive LMM showed no significant difference in vascular density compared to normal skin, though focal increases were observed.

Conclusions:

  • Increased dermal vascularity is a feature of the microenvironment underlying lentigo maligna.
  • Elevated dermal vascular density is closely associated with the presence of invasive lentigo maligna melanoma within the same specimen.