Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunophilins: structure-function relationship and possible role in microbial pathogenicity

J Hacker1, G Fischer

  • 1Institut für Molekulare Infektionsbiologie, Würzburg, Germany.

Molecular Microbiology
|November 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long-term leukemia-free survival after allogeneic marrow transplantation in patients with acute myelogenous leukemia.

Annals of hematology·1996
Same author

Influence of site specifically altered Mip proteins on intracellular survival of Legionella pneumophila in eukaryotic cells.

Infection and immunity·1995
Same author

Isolated tuberculosis of the pancreas masquerading as a pancreatic mass.

The American journal of gastroenterology·1995
Same author

T-cell epitopes of Phl p 1, major pollen allergen of timothy grass (Phleum pratense): evidence for crossreacting and non-crossreacting T-cell epitopes within grass group I allergens.

The Journal of allergy and clinical immunology·1995
Same author

[Value of endoscopic color Doppler ultrasound in the diagnosis of gastric varices and follow-up of therapeutic cyanoacrylate obliteration].

Zeitschrift fur Gastroenterologie·1995
Same author

Association of X-linked adrenoleukodystrophy with HLA DRB1 alleles.

Biochemical and biophysical research communications·1995
Same journal

Riboflavin Salvage Supports Glycolysis in Borrelia burgdorferi Through Flavin-Dependent NAD<sup>+</sup> Regeneration.

Molecular microbiology·2026
Same journal

Distinct Spatial Organisation of Rho and RNA Polymerase in Salmonella Cells.

Molecular microbiology·2026
Same journal

A Single-Nucleotide Substitution Generates a de Novo Promoter That Activates a Latent Metabolic Bypass in Escherichia coli.

Molecular microbiology·2026
Same journal

A Phosphorylation-Dependent Partner-Switching-Like Module Regulates a Glycosyltransferase Required for Heterocyst Polysaccharide Layer Formation in Anabaena sp. Strain PCC 7120.

Molecular microbiology·2026
Same journal

Chain-Length Regulation by WzzE Is Necessary for, but Genetically Separable From, Cyclic Enterobacterial Common Antigen Synthesis.

Molecular microbiology·2026
Same journal

To Move or Not to Move: When and How Bacteria Suppress Flagellar Motility.

Molecular microbiology·2026
See all related articles

Immunophilins, including cyclophilins and FK506-binding proteins, are crucial for microbial virulence. These proteins possess peptidyl prolyl cis-trans isomerase activity, aiding pathogenic bacteria survival and multiplication.

Area of Science:

  • Molecular Biology
  • Microbiology
  • Immunology

Background:

  • Immunophilins are essential housekeeping proteins found across diverse organisms.
  • Cyclophilins (Cyps) and FK506-binding proteins (FKBPs) are major immunophilin superfamilies.
  • Despite sequence differences, both Cyps and FKBPs bind specific immunosuppressive ligands.

Purpose of the Study:

  • To summarize the structure and functions of immunophilins.
  • To emphasize the role of immunophilins in pathogenic microorganism virulence.
  • To explore the peptidyl prolyl cis-trans isomerase (PPlase) activity of microbial immunophilins.

Main Methods:

  • Literature review and data synthesis on immunophilin structure and function.
  • Comparative analysis of immunophilin sequences across different organisms.

Related Experiment Videos

  • Investigation of PPlase activity and ligand-binding properties.

    • Main Results:

    • Immunophilins bind immunosuppressive drugs like cyclosporin A (Cyps) and FK506/rapamycin (FKBPs).
    • Ligand-bound immunophilins modulate T-cell signal transduction.
    • Microbial immunophilins, particularly the Mip protein of Legionella pneumophila, are virulence factors essential for bacterial survival in host cells.

    Conclusions:

    • Immunophilins exhibit conserved PPlase activity crucial for protein folding.
    • Microbial cyclophilins and FKBPs contribute significantly to pathogen virulence.
    • Understanding immunophilin function in pathogens offers potential therapeutic targets.