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Decrease in von Willebrand factor levels after a high-monounsaturated-fat diet in non-insulin-dependent diabetic

O Rasmussen¹, C Thomsen, J Ingerslev

¹Medical Department of M (Diabetes & Endocrinology), Aarhus Kommunehospital, Denmark.

Metabolism: Clinical and Experimental

|November 1, 1994

Summary

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A high-monounsaturated fatty acid (MUFA) diet significantly reduced von Willebrand factor (vWF) levels in non-insulin-dependent diabetes mellitus (NIDDM) patients. This contrasts with a high-carbohydrate diet, suggesting MUFA

Area of Science:

Endocrinology and Metabolism
Cardiovascular Health
Hemostasis and Thrombosis

Background:

Elevated von Willebrand factor (vWF) is linked to vascular complications in diabetics.
Monounsaturated fatty acids (MUFA) may improve glycemic control and blood pressure in non-insulin-dependent diabetes mellitus (NIDDM).

Purpose of the Study:

To investigate the impact of a high-MUFA diet versus a high-carbohydrate (H-CHO) diet on the hemostatic system in NIDDM patients.
To assess changes in vWF, fibrinogen, fibronectin, and alpha 2-macroglobulin levels.

Main Methods:

A crossover study involving 15 NIDDM subjects.
Patients followed either a H-MUFA diet or a H-CHO diet for 3 weeks.
Blood levels of vWF, fibrinogen, fibronectin, and alpha 2-macroglobulin were measured before and after each diet.

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Main Results:

The H-MUFA diet significantly decreased vWF levels by -12.5% (P < .004).
The H-CHO diet showed no significant change in vWF levels (5.7%, P > .05).
Fibrinogen, fibronectin, and alpha 2-macroglobulin levels remained unchanged with both diets.

Conclusions:

A diet rich in MUFA beneficially affects vWF levels in NIDDM patients.
Dietary fat composition, specifically MUFA content, may play a role in managing hemostatic risk factors for cardiovascular complications in diabetes.