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Cytogenetic effects of deltamethrin on rat bone marrow
D K Agarwal1, L K Chauhan, S K Gupta
1Industrial Toxicology Research Centre, Cell Biology Section, Lucknow, India.
Mutation Research
|November 1, 1994
Summary
Deltamethrin, a synthetic pyrethroid insecticide, causes dose-dependent DNA damage and cell cycle disruption in rats. Parenteral administration showed higher toxicity, indicating potential risks in mammals.
Area of Science:
- Toxicology
- Genetics
- Mammalian Biology
Background:
- Synthetic pyrethroids, like deltamethrin, are widely used insecticides.
- Understanding their toxicological profile is crucial for risk assessment.
Purpose of the Study:
- To investigate the in vivo cytotoxicity and genotoxicity of deltamethrin in adult female albino rats.
- To compare the effects of different administration routes (intraperitoneal, subcutaneous, oral).
Main Methods:
- Rats received single or repeated doses of deltamethrin via i.p., s.c., or oral routes.
- Mitotic index, chromosome aberrations, and micronucleated erythrocytes in bone marrow were analyzed.
Main Results:
- Deltamethrin inhibited mitotic index and increased chromosome aberrations in a dose-dependent manner.
- Parenteral administration (i.p., s.c.) was more potent in inducing cytotoxicity and genotoxicity than oral gavage.
- Endomitotic reduplication, mitotic inhibition, and micronucleus induction suggest deltamethrin's potential for mitotic spindle poisoning.
Conclusions:
- Deltamethrin exhibits significant in vivo genotoxic potential in mammals.
- The findings highlight the clastogenic effects and microtubular toxicity of deltamethrin.
- Administration route influences deltamethrin's toxicological impact.