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Circulating soluble adhesion molecules in systemic vasculitis

A A Pall1, D Adu, M Drayson

  • 1Renal Research Laboratories, Queen Elizabeth Hospital, Edgbaston, Birmingham, University of Birmingham, Birmingham, UK.

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
|January 1, 1994
PubMed
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Soluble intercellular adhesion molecule-1 (sICAM-1) and E-selectin (sE-selectin) plasma levels indicate active vasculitis. Vascular cell adhesion molecule-1 (sVCAM-1) did not show significant differences in active vasculitis patients.

Area of Science:

  • Immunology
  • Nephrology
  • Biomarker Discovery

Background:

  • Endothelial activation and injury are implicated in vasculitis pathogenesis.
  • Soluble adhesion molecules, including sICAM-1, sE-selectin, and sVCAM-1, may serve as indicators of endothelial dysfunction.
  • Assessing these markers could provide insights into vasculitis disease activity.

Purpose of the Study:

  • To evaluate plasma levels of sICAM-1, sE-selectin, and sVCAM-1 as potential biomarkers for active vasculitis.
  • To compare these levels in patients with active vasculitis, remission, chronic renal failure (CRF), and healthy controls.

Main Methods:

  • Plasma samples were collected from four groups: active vasculitis (n=16), vasculitis remission (n=15), CRF (n=10), and healthy controls (n=10).
  • Two-site ELISAs were employed to quantify plasma concentrations of sICAM-1, sE-selectin, and sVCAM-1.

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  • Statistical analyses were performed to compare marker levels across the study groups.

    • Main Results:

    • Plasma sICAM-1 levels were significantly elevated in active vasculitis patients compared to both inactive vasculitis patients and healthy controls (P < 0.001).
    • Plasma sE-selectin levels were significantly higher in active vasculitis patients versus inactive vasculitis patients (P = 0.027), but not significantly different from healthy controls (P = 0.16).
    • No significant differences in plasma sVCAM-1 levels were observed between active vasculitis, inactive vasculitis, and healthy control groups (P > 0.12).

    Conclusions:

    • Elevated plasma sICAM-1 and sE-selectin levels are associated with active vasculitis.
    • sICAM-1 and sE-selectin show potential as biomarkers for detecting active vasculitis.
    • sVCAM-1 does not appear to be a reliable marker for disease activity in vasculitis based on this study.