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Serum soluble E-selectin levels in Kawasaki disease
Scandinavian Journal of Rheumatology
|January 1, 1994
Summary
Serum soluble E-selectin (sE-selectin) levels are significantly elevated in patients with Kawasaki disease (KD) during acute and subacute phases. These elevated sE-selectin levels correlate with inflammatory markers, supporting its role in acute vasculitis.
Area of Science:
- Biochemistry
- Immunology
- Pediatrics
Background:
- Kawasaki disease (KD) is an acute febrile illness causing vasculitis in children.
- Soluble E-selectin (sE-selectin) is a marker of endothelial activation and inflammation.
Purpose of the Study:
- To investigate serum sE-selectin levels in patients with KD.
- To explore the correlation between sE-selectin and inflammatory cytokines in KD.
Main Methods:
- Serum samples were collected from KD patients during acute and subacute phases.
- Serum sE-selectin levels were measured using immunoassays.
- Levels of TNF-alpha and IL-6 were also assessed.
Main Results:
- KD patients exhibited markedly elevated serum sE-selectin levels during the acute phase (27.5 ng/ml) compared to controls (3.1 ng/ml).
- Elevated sE-selectin levels persisted into the subacute phase (16.2 ng/ml).
- Acute phase sE-selectin levels showed significant linear correlations with TNF-alpha (r2=0.64) and IL-6 (r2=0.54).
Conclusions:
- Elevated serum sE-selectin levels in KD patients provide evidence for endothelial activation during acute vasculitis.
- sE-selectin may serve as a potential biomarker for KD activity and inflammation.