Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

HPV replication in experimental models: effects of interferon

J D Gangemi1, L Pirisi, M Angell

  • 1Greenville Hospital System/Clemson University, SC 29634.

Antiviral Research
|July 1, 1994
PubMed
Summary

Interferon (IFN) therapy shows promise for human papillomaviruses (HPV) infections. This review explores animal and cell models to understand how IFN controls HPV by examining its antiviral, antiproliferative, and immunomodulatory effects.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Quantitative immunodetection of viral oncoprotein levels in human papillomavirus-transformed human cells.

Methods in molecular medicine·2011
Same author

Exercise stress increases susceptibility to influenza infection.

Brain, behavior, and immunity·2008
Same author

Quercetin reduces susceptibility to influenza infection following stressful exercise.

American journal of physiology. Regulatory, integrative and comparative physiology·2008
Same author

Loss of p53 induces epidermal growth factor receptor promoter activity in normal human keratinocytes.

Oncogene·2008
Same author

Effect of interferon alpha and cell cycle progression on translation mediated by the hepatitis C virus 5' untranslated region: a study using a transgenic mouse model.

Journal of viral hepatitis·2004
Same author

Medicine in the Noise Age: what can we believe?

Accountability in research·2002

Area of Science:

  • Virology
  • Immunology
  • Cell Biology

Background:

  • Preclinical evaluation of interferon (IFN) effectiveness against human papillomaviruses (HPV) is challenging due to difficulties in viral propagation in cell culture.
  • Despite this, IFNs, particularly alpha interferons, are widely used clinically for anogenital diseases, plantar warts, and laryngeal papillomas.
  • The precise cellular mechanisms underlying IFN's therapeutic effects on HPV-induced pathology remain incompletely understood.

Purpose of the Study:

  • To review current experimental animal and cell culture models used to investigate interferon's effects on human papillomaviruses.
  • To elucidate the antiviral, antiproliferative, and immunomodulatory mechanisms by which IFN may control HPV infection and associated pathologies.

Main Methods:

  • Review of existing literature on preclinical models for studying interferon and HPV.

Related Experiment Videos

  • Analysis of data from cell culture and animal studies investigating IFN's biological effects.
  • Focus on models that allow assessment of antiviral, antiproliferative, and immunomodulatory actions of IFN.

    • Main Results:

    • Experimental models are crucial for understanding IFN's impact on HPV, given in vitro propagation limitations.
    • IFN's multifaceted effects, including antiviral, antiproliferative, and immunomodulatory actions, are being investigated.
    • These models provide insights into the cellular basis of IFN efficacy in treating HPV-related conditions.

    Conclusions:

    • Despite challenges in preclinical research, interferon therapy is clinically relevant for HPV infections.
    • Understanding the cellular mechanisms of IFN action through experimental models is essential for optimizing HPV treatment strategies.
    • Further research using these models will clarify IFN's role in combating HPV-induced diseases.