Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interferons in human papillomavirus infections

R Cirelli1, S K Tyring

  • 1Department of Microbiology/Immunology, University of Texas Medical Branch, Galveston 77555.

Antiviral Research
|July 1, 1994
PubMed
Summary

Interferons (IFNs) are effective antiviral treatments for human papillomavirus (HPV) lesions like condyloma acuminatum (CA). Combining IFN-alpha with surgery or other therapies shows promise for managing HPV-related dysplasia and carcinoma.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tirbanibulin 1% ointment eradicates HPV-16 (+) vulvar high-grade squamous intraepithelial lesion.

Journal of the European Academy of Dermatology and Venereology : JEADV·2022
Same author

The novel AKT inhibitor afuresertib suppresses human Merkel cell carcinoma MKL-1 cell growth.

Clinical and experimental dermatology·2021
Same author

Targeting the expression of T antigens with selinexor (KPT-330) shows promise for Merkel cell polyomavirus-positive Merkel cell carcinoma treatment.

The British journal of dermatology·2021
Same author

Acquired epidermodysplasia verruciformis: a 10-year anniversary update.

The British journal of dermatology·2019
Same author

Efficacy of tildrakizumab for moderate-to-severe plaque psoriasis: pooled analysis of three randomized controlled trials at weeks 12 and 28.

Journal of the European Academy of Dermatology and Venereology : JEADV·2019
Same author

Polyomaviruses of the skin: integrating molecular and clinical advances in an emerging class of viruses.

The British journal of dermatology·2018

Area of Science:

  • Virology
  • Oncology
  • Immunology

Background:

  • Human papillomavirus (HPV) infections cause benign warts (condyloma acuminatum, CA) and can lead to dysplasia and carcinoma.
  • Current treatments for HPV lesions are primarily anti-tumor (chemotherapy, cryotherapy, surgery), not anti-viral.

Purpose of the Study:

  • To review the efficacy of interferons (IFNs) as anti-viral therapy for HPV-related lesions.
  • To explore the use of IFNs in managing HPV-related dysplasia and carcinoma.

Main Methods:

  • Review of studies evaluating IFN-alpha, IFN-beta, and IFN-gamma for condyloma acuminatum (CA).
  • Analysis of combination therapies involving IFNs for HPV-related dysplasia and carcinoma.

Main Results:

  • IFN-alpha demonstrates efficacy in treating CA via various administration routes, schedules, and dosages with a good safety profile.
  • Surgical removal of lesions followed by subcutaneous local IFN-alpha yielded the highest success rates in reducing CA recurrence.
  • Combination therapy, such as IFN-alpha with retinoids for cervical carcinoma, shows potential.

Conclusions:

  • Interferons are the only approved anti-viral drugs for benign HPV lesions.
  • Future HPV lesion control strategies will likely involve IFNs combined with non-antiviral therapies and cytokine inducers.

Related Experiment Videos