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Differences in antigenicity of E2 in Semliki Forest virus particles and in infected cells
1Institute of Medical Virology, Justus-Leibig University Giessen, Federal Republic of Germany.
Archives of Virology
|January 1, 1994
Abstract:
Using six monoclonal antibodies to epitopes a-f on the glycoprotein E2 of Semliki Forest virus (SFV) we found antigenic differences between E2 in infected cells and in virus particles, respectively, if glycosylation was impaired by 2-deoxy-D-glucose or inhibited by N-methyl-1-deoxynojirimycin. Furthermore we concluded that a conformational change of E2 takes place on virus budding.