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Angiogenesis: potential therapy for ischaemic disease

J F Symes1, A D Sniderman

  • 1Department of Surgery, St Elizabeth's Medical Center of Boston, Massachusetts.

Current Opinion in Lipidology
|August 1, 1994
PubMed
Summary

Polypeptide mitogens stimulate blood vessel growth, offering potential treatments for ischaemic syndromes. Research shows these angiogenic agents enhance collateral vessel development in animal models.

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Area of Science:

  • Biomedical research
  • Vascular biology
  • Regenerative medicine

Background:

  • Ischaemic syndromes are characterized by insufficient blood flow.
  • Inflammation associated with ischaemia/necrosis upregulates growth factors.
  • Polypeptide mitogens stimulate angiogenesis, the formation of new blood vessels.

Purpose of the Study:

  • To explore the therapeutic potential of angiogenic agents for ischaemic conditions.
  • To investigate the role of growth factors and receptor response in ischaemia.
  • To evaluate the efficacy of exogenous angiogenic agents in promoting collateral vessel growth.

Main Methods:

  • Administration of various exogenous angiogenic agents.
  • Utilizing animal models of myocardial, peripheral arterial, and cerebral insufficiency.
  • Assessing the growth of collateral vessels.

Main Results:

  • Exogenous angiogenic agents promoted collateral vessel growth.
  • Enhanced growth observed in models of myocardial insufficiency.
  • Enhanced growth observed in models of peripheral arterial insufficiency.
  • Enhanced growth observed in models of cerebral insufficiency.

Conclusions:

  • Therapeutic angiogenesis shows significant promise for treating ischaemic syndromes.
  • Angiogenic agents can effectively stimulate collateral vessel formation.
  • Further clinical research is warranted to explore therapeutic angiogenesis potential.

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