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The effects of a long term treatment with cyclophosphamide on the thymus and on some blood parameters in Wistar rats
R Giurgea1, C Roşioru, I Roman
1Institute of Biological Research, Cluj-Napoca Faculty of Biology, Cluj-Napoca.
Romanian Journal of Physiology : Physiological Sciences
|January 1, 1993
Abstract:
Adult Wistar rats of both sexes were treated with Cyclophosphamide (a Romanian product), for 12 month. The Cyclophosphamide was given in the food, in 3 different doses (0.31, 1.25, respectively 2.5 mg/kg body weight). The modifications produced in the thymus and blood plasma were dose and sex dependent, and they emphasize an alteration in the protein metabolism, which is not accompanied by an involuntion of the thymus itself.