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Obesity and benign prostatic hyperplasia

E Giovannucci1, E B Rimm, C G Chute

  • 1Channing Laboratory, Department of Medicine, Harvard Medical School, Boston, MA.

American Journal of Epidemiology
|December 1, 1994
PubMed
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Abdominal obesity is linked to a higher risk of benign prostatic hyperplasia (BPH) and more severe urinary symptoms in men. Men with larger waistlines were more likely to need prostate surgery or report frequent urinary issues.

Area of Science:

  • Urology
  • Endocrinology
  • Epidemiology

Background:

  • Abdominal obesity is hypothesized to influence benign prostatic hyperplasia (BPH) development and urinary obstructive symptoms through increased estrogen-to-androgen ratio and sympathetic nervous activity.
  • Obesity, particularly abdominal obesity, is a growing public health concern with potential links to various chronic conditions.

Purpose of the Study:

  • To investigate the association between abdominal obesity and the incidence of prostatectomy for BPH.
  • To examine the relationship between abdominal obesity and the frequency and severity of urinary obstructive symptoms in men without a prior prostatectomy.

Main Methods:

  • A prospective cohort study involving 25,892 men aged 40-75 from the Health Professionals Follow-up Study.
  • Data collected on weight, height, waist, and hip circumferences in 1986-1987, with follow-up for prostatectomy incidence until 1992.

Related Experiment Videos

  • Assessment of urinary symptom frequency and severity via questionnaire in 1992.

    • Main Results:

    • Abdominal obesity, indicated by a waist circumference ≥ 43 inches (109 cm), was significantly associated with an increased likelihood of prostatectomy for BPH (OR = 2.38).
    • Men with larger waist circumferences also reported more frequent urinary symptoms, even without surgery (OR = 2.00).
    • Waist circumference was the primary measure of abdominal obesity associated with BPH outcomes, independent of body mass index, hip circumference, or waist-to-hip ratio.

    Conclusions:

    • Abdominal obesity is a significant risk factor for benign prostatic hyperplasia, increasing both the likelihood of requiring prostatectomy and the severity of urinary obstructive symptoms.
    • Targeting abdominal fat reduction may be a potential strategy for managing or preventing BPH and associated urinary issues in men.
    • Waist circumference serves as a key indicator for assessing the risk of BPH-related outcomes linked to abdominal obesity.