Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Pathologic classification of soft tissue sarcomas

¹Department of Pathology, Virginia Commonwealth University, Medical College of Virginia, Richmond 23219.

Seminars in Surgical Oncology

|September 1, 1994

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Diagnostic pitfalls in fine-needle aspiration cytology of temporomandibular chondroblastoma: report of two cases.

Diagnostic cytopathology·2006

Same author

Posttransplantation lymphoproliferative disorder: osseous and hepatic involvement.

AJR. American journal of roentgenology·2001

Same author

Cervical screening by neural networks.

Cancer·2001

Same author

Fine-needle aspiration biopsy of nonpalpable breast lesions in a multicenter clinical trial: results from the radiologic diagnostic oncology group V.

Radiology·2001

Same author

Soft tissue aspiration cytopathology of malignant lymphoma and leukemia.

Cancer·2001

Same author

Competency assessment and proficiency testing.

Acta cytologica·2000

Same journal

Preoperative chemoradiation for locally advanced rectal cancer: rationale, technique, and results of treatment.

Seminars in surgical oncology·2003

Same journal

Preoperative chemoradiation for locally advanced rectal adenocarcinoma-the University of Florida experience.

Seminars in surgical oncology·2003

Same journal

Postoperative adjuvant therapy for pancreatic cancer.

Seminars in surgical oncology·2003

Same journal

Conformal chemoradiation for primary and metastatic liver malignancies.

Seminars in surgical oncology·2003

Same journal

Gastrectomy, peritonectomy, and perioperative intraperitoneal chemotherapy: the evolution of treatment strategies for advanced gastric cancer.

Seminars in surgical oncology·2003

Same journal

Combined modality therapy in esophageal cancer: the Memorial experience.

Seminars in surgical oncology·2003

See all related articles

Immunological markers and chromosomal abnormalities aid in soft tissue sarcoma diagnosis and management. However, their specificity and diagnostic approval require further rigorous evaluation for clinical utility.

Area of Science:

Oncology
Pathology
Genetics

Background:

Immunological markers and chromosomal abnormalities are investigated for their role in soft tissue sarcoma (STS) diagnosis, prognosis, and management.
Existing chromosomal abnormalities in STS are often reported in limited case series, hindering the establishment of their clinical significance.
Current immunological markers lack the specificity and sensitivity for definitive tumor classification and are not widely approved for diagnostic use.

Purpose of the Study:

To review the current landscape of immunological markers and chromosomal abnormalities in soft tissue sarcomas.
To assess the diagnostic and prognostic utility of these markers and abnormalities in clinical practice.
To highlight the need for rigorous evaluation of novel markers and abnormalities.

Main Methods:

Related Experiment Videos

Review of existing literature on immunological markers and chromosomal abnormalities in soft tissue sarcomas.
Analysis of the reported specificity, sensitivity, and clinical significance of these findings.
Evaluation of the current role of these markers in the context of conventional histopathology and staging.

Main Results:

No single immunological marker is fully specific or sensitive for a particular soft tissue sarcoma type.
Chromosomal abnormalities, while potentially specific, have limited data supporting their widespread diagnostic or prognostic value.
Immunological reagents are primarily used as supportive tools alongside conventional pathology, grading, and staging.

Conclusions:

Immunological markers and chromosomal abnormalities currently serve a supporting role in the management of soft tissue sarcomas.
Antibodies used in diagnosis should be applied in panels, not as single tests, to enhance diagnostic accuracy.
Future research must rigorously validate the specificity, sensitivity, and clinical utility of new markers and abnormalities for STS.