Quantitative-comparative histology of prostatic adenomas in medically and surgically treated patients

Transvesical adenectomy was done in 60 men with prostatic adenomas, including 40 pretreated medically (20 with prazosin, 20 with Tadenan). The resected material was sampled for histologic examination. Glandular, smooth muscle and fibrotic tissues as well as inflammatory foci were assessed quantitatively by planimetry. No adenomas consisting solely of glandular hyperplasia were found. In adenomas from patients pretreated with prazosin smooth muscle tissue was predominant and postinflammatory lesions were the least frequently observed. In Tadenan-pretreated patients quantitative predominance of glandular and fibrotic tissues was found and smooth muscle constituted the smallest part of the adenomas. Patients who had undergone surgery only had adenomas in which focal inflammation predominated.