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Related Experiment Videos

Pharmacotherapy for benign prostatic hyperplasia

P Narayan1, R Indudhara

  • 1Division of Urology, University of California, School of Medicine, San Francisco.

The Western Journal of Medicine
|November 1, 1994
PubMed
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Benign prostatic hyperplasia (BPH) affects aging men, with symptoms often requiring surgery. New therapies, including alpha-blockers and androgen blockers, offer alternatives to traditional prostate surgery.

Area of Science:

  • Urology
  • Andrology
  • Pharmacology

Background:

  • Benign prostatic hyperplasia (BPH) is a common condition in aging men, characterized by prostate enlargement.
  • Microscopic BPH is prevalent (70% by age 70), but symptomatic BPH requiring intervention affects 30% of men.
  • Intraprostatic androgens are crucial for prostate growth, and BPH pathogenesis is multifactorial.

Purpose of the Study:

  • To review alternative therapies for benign prostatic hyperplasia (BPH).
  • To discuss alpha-adrenergic blockers and androgen-blocking agents for BPH management.
  • To present updated, cost-effective recommendations for BPH evaluation.

Main Methods:

  • Review of existing literature on BPH treatments.
  • Analysis of transurethral resection of the prostate (TURP) morbidity rates.

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  • Evaluation of alpha-adrenergic blockers and androgen-blocking drug mechanisms and side effects.

    • Main Results:

    • Transurethral resection of the prostate (TURP) has a persistent 18% morbidity rate over 30 years.
    • Alpha-adrenergic blockers relax the prostatic urethra, alleviating BPH symptoms.
    • Androgen-blocking drugs are available for clinical use, targeting prostate growth.

    Conclusions:

    • High morbidity associated with TURP necessitates alternative BPH therapies.
    • Alpha-adrenergic blockers and androgen-blocking agents represent viable treatment options.
    • Updated, comprehensive, and cost-effective BPH evaluation strategies are recommended.