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Related Experiment Videos

CD46, a primate-specific receptor for measles virus

R E Dörig1, A Marcil, C D Richardson

  • 1Biotechnology Research Institute, National Research Council of Canada, Montréal.

Trends in Microbiology
|September 1, 1994
PubMed
Summary

Measles virus infects primate cells using the CD46 receptor. Introducing human CD46 into rodent cells makes them susceptible, enabling new antiviral and vaccine testing models.

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Area of Science:

  • Virology
  • Immunology
  • Cell Biology

Background:

  • Measles virus (MeV) typically infects only primate cells.
  • The cellular receptor for MeV has been identified as CD46 (membrane cofactor protein).

Purpose of the Study:

  • To investigate the role of CD46 as the measles virus receptor.
  • To explore the potential of genetically modified animals for MeV research.

Main Methods:

  • Transfection of rodent cells with the human CD46 gene.
  • Assessing the susceptibility of transfected cells to measles virus infection.

Main Results:

  • Rodent cells engineered to express human CD46 became susceptible to measles virus.
  • This demonstrates CD46's crucial role in mediating measles virus entry.

Conclusions:

  • CD46 is the primary receptor enabling measles virus entry into primate cells.
  • Transgenic animals expressing human CD46 offer a promising platform for developing and evaluating measles antiviral therapies and vaccines.

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