Evaluation of indeterminate sera for hepatitis C virus by assays using synthetic peptides
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D Rivanera1, G Lorino, D Lilli
1Istituto di Microbiologia, Facoltà di Medicina e Chirurgia La Sapienza, Rome, Italy.
Abstract:
The development of new immunodiagnostic systems to study antibodies anti-HCV based on the use of synthetic peptides are potentially very important in the evaluation of indeterminate samples. We have compared two immunodiagnostic tests, the 3-RIBA and LIA-HCV test system, to examine the samples rated as indeterminate by the 2-RIBA test. The results showed that the specificity of the new tests has improved, in fact 29/40 of the indeterminate samples studied became positive with both tests. However, the 3-RIBA test showed higher sensitivity, since two samples negative by LIA-HCV, were positive with this system.
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