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Menthol and related cooling compounds

R Eccles1

  • 1Department of Physiology, University of Wales College of Cardiff, UK.

The Journal of Pharmacy and Pharmacology
|August 1, 1994
PubMed
Summary
This summary is machine-generated.

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Menthol and cooling agents are common in many products. This review details their production, chemistry, and effects on nerves and muscles, impacting various body systems.

Area of Science:

  • Pharmacology
  • Toxicology
  • Chemistry

Background:

  • Menthol and related cooling compounds are prevalent in numerous consumer products, including medications, personal care items, and pesticides.
  • These compounds are known for their sensory effects, particularly cooling sensations.

Purpose of the Study:

  • To provide a comprehensive review of menthol and related cooling agents.
  • To discuss their production, chemistry, metabolism, mechanism of action, pharmacology, and toxicology.

Main Methods:

  • Literature review synthesizing information on menthol's properties and effects.
  • Analysis of structure-activity relationships and pharmacological actions.

Main Results:

  • Menthol's coolant and carminative actions are linked to its effects on calcium channels in sensory nerves and smooth muscle.

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  • The review covers menthol's impact on the nose, respiratory reflexes, oral cavity, skin, and gastrointestinal tract.

    • Conclusions:

    • Menthol exhibits diverse physiological effects mediated through specific molecular pathways.
    • Understanding menthol's actions is crucial for its application in various industries and products.