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An immortalised murine hypothalamic neuronal cell, GT1-7, expresses functional histamine H1 receptors
M R Zamani1, J R Dupere, D R Bristow
1School of Biological Sciences, Division of Neuroscience, University of Manchester, UK.
Neuroscience Letters
|August 29, 1994
Abstract:
Histamine, acting via H1 receptors, dose-dependently stimulated [3H]inositol phosphate production in GT1-7 neuronal cells. GT1-7 cells also responded to Substance P but not to other neuroactive drugs tested. Acute histamine pretreatment desensitised the histamine-induced response, resulting in a reduction in the maximal response and a slower time-course of [3H]-inositol phosphate production. The desensitisation phenomenon was reversible, with full recovery by 2 h.