Related Experiment Videos
Renal cell carcinomatous meningitis: pathologic and immunohistochemical features
P B Crino1, R A Sater, M Sperling
1Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia.
Neurology
|January 1, 1995
Summary
This study details a rare case of widespread meningeal carcinomatosis originating from renal cell carcinoma. The findings highlight specific tumor cell subtypes and their infiltration patterns within the central nervous system.
Area of Science:
- Oncology
- Neuropathology
- Nephrology
Background:
- Meningeal carcinomatosis is a serious complication of advanced cancer.
- Renal cell carcinoma (RCC) rarely metastasizes to the meninges.
Observation:
- A patient presented with widespread meningeal carcinomatosis secondary to renal cell carcinoma.
- Tumor cells exhibited clear and spindle cell morphology.
- Infiltration involved the meninges of the cauda equina, oculomotor nerve, spinal cord, and cerebral hemispheres.
Findings:
- Tumor cells formed abortive glandular or tubular aggregates.
- No evidence of direct parenchymal invasion was observed.
- Immunohistochemistry showed positive labeling for Cytokeratin (Cam 5.2) epitopes.
- Epithelial membrane antigen and neuron-specific enolase were negative.
Implications:
- This case expands the understanding of rare metastatic patterns in renal cell carcinoma.
- Highlights the importance of considering RCC in the differential diagnosis of meningeal carcinomatosis.
- Provides insights into the immunohistochemical profile aiding in diagnosis.