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pp60c-src expression in rat spermatogenesis

H Nishio¹, M Tokuda, T Itano

¹First Department of Physiology, Kagawa Medical School, Japan.

Biochemical and Biophysical Research Communications

|January 17, 1995

Summary

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pp60c-src kinase activity is present in rat testes and its expression increases during development, coinciding with spermatogenesis. This suggests pp60c-src plays a role in male reproductive cell development.

Area of Science:

Molecular Biology
Reproductive Biology
Cell Signaling

Background:

pp60c-src is a non-receptor tyrosine kinase.
Its role in male reproductive development is not fully understood.

Purpose of the Study:

To investigate the expression and role of pp60c-src during rat spermatogenesis.

Main Methods:

Fractionation of rat testes membrane extracts.
Immunecomplex kinase assay using a monoclonal antibody (mAb327).
Immunohistochemical staining.

Main Results:

pp60c-src kinase activity and protein levels increase during rat testes development.
Peak activity coincides with the onset of meiosis.

Related Experiment Videos

pp60c-src is highly expressed in spermatids (post-meiotic cells).

Conclusions:

pp60c-src is a developmentally regulated protein in rat testes.
pp60c-src is likely involved in the process of spermatogenesis.