Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Functional characterization of antiadhesion molecules

S Hoffman1, S L Dutton, H Ernst

  • 1Medical University of South Carolina, Division of Rheumatology, Charlston 29425.

Perspectives on Developmental Neurobiology
|January 1, 1994
PubMed
Summary

Cytotactin acts as an anti-adhesion molecule, inhibiting cell spreading and impacting immune cell function. Its presence near tumors suggests a role in regulating inflammation and immune surveillance of cancer.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation of the exposure, dose-response and fate in the lung and pleura of chrysotile-containing brake dust compared to TiO<sub>2</sub>, chrysotile, crocidolite or amosite asbestos in a 90-day quantitative inhalation toxicology study - Interim results Part 1: Experimental design, aerosol exposure, lung burdens and BAL.

Toxicology and applied pharmacology·2019
Same author

Evaluation of the dose-response and fate in the lung and pleura of chrysotile-containing brake dust compared to TiO<sub>2</sub>, chrysotile, crocidolite or amosite asbestos in a 90-day quantitative inhalation toxicology study - Interim results Part 2: Histopathological examination, Confocal microscopy and collagen quantification of the lung and pleural cavity.

Toxicology and applied pharmacology·2019
Same author

Evaluation of the dose-response and fate in the lung and pleura of chrysotile-containing brake dust compared to chrysotile or crocidolite asbestos in a 28-day quantitative inhalation toxicology study.

Toxicology and applied pharmacology·2018
Same author

Investigation of Chronic Toxic and Carcinogenic Effects of Gasoline Engine Exhausts Deriving from Fuel without and with Ferrocene Additive.

Inhalation toxicology·2015
Same author

Evaluation of the fate and pathological response in the lung and pleura of brake dust alone and in combination with added chrysotile compared to crocidolite asbestos following short-term inhalation exposure.

Toxicology and applied pharmacology·2015
Same author

Risk of complications due to anticoagulation during dermatosurgical procedures: a systematic review and meta-analysis.

Journal of the European Academy of Dermatology and Venereology : JEADV·2014

Area of Science:

  • Cell Biology
  • Immunology
  • Extracellular Matrix Biology

Background:

  • Extracellular matrix (ECM) proteins like cytotactin and CTB proteoglycan function as anti-adhesion molecules.
  • These molecules inhibit cell spreading and attachment, contrasting with fibronectin and laminin which promote these processes.
  • Cell behavior is regulated by the interplay between pro-adhesion and anti-adhesion signals.

Purpose of the Study:

  • To investigate the role of cytotactin in cell behavior and immune responses.
  • To explore the implications of cytotactin's anti-adhesion properties in the context of tumor microenvironments.

Main Methods:

  • Studied the effects of cytotactin on eosinophil spreading and viability on laminin.
  • Examined monocyte migration through Matrigel in response to tumor necrosis factor, with and without cytotactin coating.

Related Experiment Videos

  • Correlated cytotactin expression levels in breast tissue with tumor presence.

    • Main Results:

    • Cytotactin inhibited eosinophil spreading, actin-rich foci formation, and viability on laminin.
    • Monocyte migration towards tumor necrosis factor was blocked by cytotactin coating.
    • Cytotactin is highly expressed in the stroma surrounding adult breast tumors, but not in normal tissue.

    Conclusions:

    • Cytotactin's anti-adhesion properties significantly impact cell behavior and immune cell function.
    • Cytotactin plays a crucial role in regulating inflammation and immune surveillance of tumors.
    • The differential expression of cytotactin in breast tissue suggests its involvement in cancer progression.