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Inhibitory effect of calf fetuin on the cytotoxic activity of LAK cell-derived factors and tumor necrosis factor

Chertov OYu1, M V Ermolaeva, D K Satpaev

  • 1Shemyakin Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow.

Immunology Letters
|September 1, 1994
PubMed

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NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
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The heterodimer of NF-κB...