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Novel assay for the influenza virus M2 channel activity
K Giffin1, R K Rader, M H Marino
1Department of Protein Biochemistry, Searle Research and Development, St. Louis, MO.
FEBS Letters
|January 9, 1995
Abstract:
The influenza A M2 ion channel was expressed and activity characterized in Xenopus oocytes. Based on the activation properties of the channels, a high throughput, non-electrophysiological screening assay was developed in order to identify novel inhibitors of the channel. This will facilitate discovery of novel agents to treat influenza viral infections.