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Updated: Aug 15, 2026

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The Lambda Select cII Mutation Detection System
Published on: April 26, 2018
Mutagenicity of carboline methyl derivatives in Salmonella
I Rahden-Staroń1, W Peczyńska-Czoch, L Kaczmarek
1Department of Biochemistry, Medical School, Warsaw, Poland.
Abstract:
A series of linear, methyl-substituted derivatives of 5H-indolo[2,3-b] quinolines was tested for mutagenic activity with the battery of Ames tester strains. Mutagenic activity of indoloquinolones was strongly influenced by the position and a number of methyl groups. All compounds tested, with one exception, act like frame-shift mutagens. Only two compounds among them were mutagenic in the strain detecting oxidative and cross-linking mutagens.

