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Nephrotoxicity of immunosuppressive drugs
W M Bennett1, E Burdmann, T Andoh
1Division of Nephrology, Hypertension and Clinical Pharmacology, Oregon Health Sciences University, Portland 97201.
Mineral and Electrolyte Metabolism
|January 1, 1994
Abstract:
Drugs used to modify the immune response in solid organ transplantation or autoimmune disease may cause dose-related nephrotoxicity. Cyclosporine, FK506, cyclosporine G, and rapamycin have all been studied experimentally and to a more limited extent in patients. This paper summarizes this literature using data from clinically relevant animal models.