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Synovial tissue response to treatment with Campath-1H
E M Ruderman1, M E Weinblatt, L M Thurmond
1Brigham and Women's Hospital, Boston, Massachusetts.
Objective:
Therapeutic trials in rheumatoid arthritis with the monoclonal antibody Campath-1H have demonstrated recurrent clinical synovitis in some patients, despite profound depletion of circulating lymphocytes. This study was undertaken to examine the cellular infiltrates in synovial tissue at a time of persistent peripheral lymphopenia.
Methods:
Immunohistochemical staining of synovial tissue and peripheral blood lymphocyte phenotyping.
Results:
Synovial tissues from 2 patients with recurrent synovitis after Campath-1H therapy contained significant T lymphocytic infiltrates at a time when circulating T lymphocytes were markedly depleted.
Conclusion:
These results demonstrate that peripheral blood analysis may not accurately reflect the synovial tissue response to monoclonal antibody therapy.
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