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Serum stem cell factor levels in patients with aplastic anemia

S D Nimer1, D H Leung, M J Wolin

  • 1Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.

International Journal of Hematology
|October 1, 1994
PubMed
Summary

Serum levels of stem cell factor (SCF), a key hematopoietic growth factor, were found to be significantly lower in patients with acquired aplastic anemia compared to healthy individuals. This finding suggests a potential role for deficient SCF production in the disease

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Area of Science:

  • Hematology
  • Immunology
  • Cell Biology

Background:

  • Acquired aplastic anemia pathogenesis involves immune suppression of hematopoiesis.
  • Abnormalities in T cells, bone marrow stromal cells, and cytokine production are reported in aplastic anemia.
  • Stem cell factor (SCF) is an early-acting hematopoietic growth factor produced by bone marrow stromal cells.

Purpose of the Study:

  • To investigate potential abnormalities in stem cell factor (SCF) production in patients with aplastic anemia.
  • To evaluate serum levels of SCF in aplastic anemia patients and compare them to normal controls.

Main Methods:

  • Serum SCF levels were measured in 25 patients diagnosed with aplastic anemia.
  • Serum SCF levels were compared to those of 257 healthy individuals.

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  • SCF levels were analyzed for correlations with patient age, disease duration, and blood counts.

    • Main Results:

    • Mean serum SCF levels were significantly lower in aplastic anemia patients (2.7 ng/ml) than in normal controls (3.3 ng/ml) (P=0.011).
    • SCF levels did not correlate with patient age, disease duration, white blood cell count, platelet count, or hematocrit.

    Conclusions:

    • Aplastic anemia patients exhibit reduced serum levels of stem cell factor (SCF).
    • Deficient production of stromally derived hematopoietic growth factors like SCF may be implicated in aplastic anemia.
    • Further research is needed to identify underlying causes of deficient SCF production in this disorder.