Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

CD40 ligation in B cell activation, isotype switching and memory development

D Gray1, K Siepmann, G Wohlleben

  • 1Department of Immunology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.

Seminars in Immunology
|October 1, 1994
PubMed
Summary

CD40 ligation is vital for B cell activation and antibody production. Early CD40 signals are crucial for developing memory B cells, though the exact mechanisms require further investigation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of a broadband hard x-ray radiography platform for pulsed-power experiments.

The Review of scientific instruments·2026
Same author

Primary ciliary dyskinesia: Meeting the challenges of diagnosis in South Africa.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2024
Same author

Aetiology of pleural effusions in children living in a high TB endemic setting.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2024
Same author

Abstracts of presentations to the Annual Meetings of the Canadian Society of Colon and Rectal Surgeons Canadian Association of General Surgeons Canadian Association of Thoracic Surgeons: Canadian Surgery Forum, London, Ont., Sept. 19 to 22, 2002.

Canadian journal of surgery. Journal canadien de chirurgie·2023
Same author

Canadian Surgery Forum 2018: St. John's, NL Sept. 13-15, 2018.

Canadian journal of surgery. Journal canadien de chirurgie·2022
Same author

Canadian Surgery Forum: Abstracts of presentations to the Annual Meetings of the Canadian Association of Bariatric Physicians and Surgeons, Canadian Association of General Surgeons, Canadian Association of Thoracic Surgeons, Canadian Hepato-Pancreato-Biliary Society, Canadian Society of Surgical Oncology, Canadian Society of Colon and Rectal Surgeons, London, Ont. Sept. 15-18, 2011.

Canadian journal of surgery. Journal canadien de chirurgie·2022

Area of Science:

  • Immunology
  • Cellular Biology

Background:

  • CD40 interaction with its ligand on T helper cells is essential for T-dependent antibody responses.
  • The precise role and timing of CD40 ligation in B cell differentiation remain under investigation.

Purpose of the Study:

  • To elucidate the direct and indirect consequences of CD40 ligation on B cell differentiation.
  • To explore the influence of CD40 on isotype switching and memory B cell development.
  • To assess the CD40L-independence of certain T-dependent antibody responses.

Main Methods:

  • In vivo experiments blocking CD40 ligation.
  • Analysis of B cell activation, isotype switching, and memory B cell generation.

Main Results:

  • CD40 ligation directly impacts B cell activation.

Related Experiment Videos

  • Early CD40 signals are critical for memory B cell precursor generation.
  • The observed importance of early CD40 signals may relate to subsequent programming and survival.

    • Conclusions:

    • CD40 ligation plays a multifaceted role in adaptive immunity, particularly in B cell maturation and memory formation.
    • Further research is needed to fully delineate the direct vs. indirect effects of CD40 signaling pathways.