[Mechanisms responsible for protective effect of Sini decoction on ischemic myocardium in mice]

The possible mechanisms responsible for the protective effect of Sini decoction (SND) on the ischemic myocardium were studied on the mice model of pituitrin-induced myocardial ischemia in terms of free radical. Results indicated that SND significantly decreased the concentration of oxygen free radical and the content of malondialdehyde (MDA), increased nutritional blood flow and the activity of superoxide dismutase (SOD) in ischemic myocardium. These results suggested that three mechanisms whereby SND exerted its protective effects existed; improving the perfusion of ischemic myocardium, attenuating the injurious action of free radical and strengthening the free radical defense.